This assay is available in New York State
Cerebrospinal Fluid (CSF)
Sterile screw capped vial
Collect entire sample into a single sterile tube
Freeze as soon as possible after collection
Room Temperature: Not stable; Refrigerated: 24 hours; Frozen: 72 hours @ -20C, Indefinitely @ -80C; Freeze/Thaw: None
Bloody CSF; Received thawed
CSF 5-Methyltetrahydrofolate is useful for determining a deficiency of folate in the central nervous system. CSF 5-Methyltetrahydrofolate (NC01) may also be used for assessment of Variants of Uncertain Significance (VUS) identified during genetic testing (e.g. Next Generation Sequencing or Capillary Sequencing Testing).
CLINICAL 5-Methyltetrahydrofolate (5-MTHF) is the predominant form of folate in cerebrospinal fluid (CSF). Low CSF 5-MTHF levels are associated with inborn errors of metabolism affecting folate metabolism, dietary deficiency of folate, cerebral folate syndromes and Kearns-Sayre syndrome. Symptoms may include, anemia, developmental delay, seizures, depression and dementia.
CSF Collection Tubes (set of 5 tubes per kit)
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|620008||5-Methyltetrahydrofolate (CSF)||47547-5||620000||5-MTHF Result||47547-5|
|620008||5-Methyltetrahydrofolate (CSF)||47547-5||620001||5-MTHF Interpretation||N/A|